Open AccessEye‐of‐the‐Tiger sign is not Pathognomonic of Pantothenate Kinase‐Associated Neurodegeneration in Adult Cases
Author(s) -
Chang ChawLiang,
Lin ChihMing
Publication year - 2011
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.8
Subject(s) - pathognomonic , neurodegeneration , sign (mathematics) , tiger , neuroscience , medicine , psychology , pathology , disease , computer science , mathematical analysis , mathematics , computer security
An eye‐of‐the‐tiger sign is previously known to have one‐to‐one correlation with pantothenate kinase‐associated neurodegeneration (PKAN). Reviewing the literature on this subject, the correlation between eye‐of‐the‐tiger sign and PKAN seems to show an interesting hypothesis that differs from conventional conclusion. We analyze the published papers in an attempt to reflect this trend and illustrate our points with findings in a 39‐year‐old man. His brain magnetic resonance imaging study shows typical eye‐of‐the‐tiger sign suggestive of PKAN. Genetic analyses revealed no mutations in pantothenate kinase 2.