Open AccessDetection and application of neurochemical profile by multiple regional 1 H‐MRS in Parkinson's disease
Author(s) -
Guan Jitian,
Rong Yu,
Wen Ye,
Wu Huanze,
Qin Hong,
Zhang Qingying,
Chen Wei
Publication year - 2017
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.792
Subject(s) - cuneus , neurochemical , substantia nigra , globus pallidus , medicine , neurochemistry , parkinson's disease , hippocampus , neuroscience , endocrinology , neurology , psychology , basal ganglia , central nervous system , disease , precuneus , functional magnetic resonance imaging
The accurate diagnosis and monitoring of idiopathic Parkinson disease ( PD ), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify a neurochemical profile in multiple regions of the PD brain and healthy controls by proton magnetic resonance spectroscopy ( 1 H‐ MRS ). We aimed to track changes of the brain neurochemical, quantify neuronal loss, and further determine the diagnostic value of 1 H‐ MRS . Methods PD patients and healthy controls recruited from Second Affiliated Hospital of Shantou University Medical College, Shantou, southern China, underwent 1 H‐ MRS . Chemical information was obtained for ratios of N‐acetylaspartate to creatine ( NAA /Cr), NAA to choline ( NAA /Cho), and Cho to Cr for substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus, and dorsal thalamus regions. Results Compared to the 20 healthy controls (12 male, age 58.75 ± 5.03 years), the 42 patients (21 male, age 61.60 ± 6.40 years) showed lower NAA /Cr and NAA /Cho ratios in substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus and dorsal thalamus regions ( p < .01); NAA /Cr and NAA /Cho ratios were reduced for both patients with unilateral and mild/no cognitive impairment ( p < .01); Unified Parkinson's Disease Rating Scale score was inversely correlated with NAA /Cr ratios in the substantia nigra ( r = −.32; p = .042). Conclusion NAA /Cr and NAA /Cho ratios may be useful metabolic biomarkers for early diagnosis of PD . Multi‐voxel 1 H‐ MRS can provide information on brain neurochemistry and may be a promising technique for diagnosis of and monitoring neuronal loss in PD .