Open AccessSerum galectin‐3 levels and delirium among postpartum intensive care unit women
Author(s) -
Zhu Ying,
Hu Wei,
Zhu MingLi,
Yin Ting,
Su Jun,
Wang JianRong
Publication year - 2017
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.773
Subject(s) - delirium , biomarker , medicine , c reactive protein , proinflammatory cytokine , intensive care unit , prospective cohort study , inflammation , intensive care medicine , biology , biochemistry
Objective Inflammation correlates with delirium. Galectin‐3 is a proinflammatory protein. This study aimed to determine relation of serum galectin‐3 levels to delirium of postpartum intensive care unit ( ICU ) women. Materials and Methods In this prospective observational study, serum galectin‐3, S100B, and C‐reactive protein levels of 412 postpartum ICU women and 412 healthy women were measured. Delirium and Acute Physiology and Chronic Health Care Evaluation II ( APCHCE II ) scores were recorded. Results Serum levels of galectin‐3, S100B, and C‐reactive protein were significantly elevated in the postpartum women than in the healthy women. Galectin‐3 levels were highly associated with APCHCE II scores and S100B and C‐reactive protein levels. Galectin‐3, C‐reactive protein, and S100B levels and APCHCE II scores were identified as independent predictors for delirium. Area under the curve ( AUC ) of serum galectin‐3 levels was similar to that of S100B levels, and significantly exceeded those of C‐reactive protein levels and APCHCE II scores. Moreover, galectin‐3 significantly improved the AUC s of APCHCE II scores, S100B levels, and C‐reactive protein levels. Conclusions Galectin‐3, involved in inflammatory process underlying delirium‐related brain injury, might be a potential biomarker to predict delirium of postpartum ICU women.