Open AccessAssociations between cognitive impairment and motor dysfunction in Parkinson's disease
Author(s) -
Wang YiXuan,
Zhao Jue,
Li DaKe,
Peng Fang,
Wang Ying,
Yang Ke,
Liu ZhenYang,
Liu FengTao,
Wu JianJun,
Wang Jian
Publication year - 2017
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.719
Subject(s) - cognition , parkinson's disease , executive dysfunction , neuropsychology , psychology , executive functions , verbal memory , verbal fluency test , disease , audiology , physical medicine and rehabilitation , association (psychology) , medicine , psychiatry , psychotherapist
Numerous studies have been carried out to explore the potential association between neurologic deficits and variable clinical manifestations of Parkinson's disease ( PD ). The aim of our study was to investigate the association between cognitive performance and motor dysfunction in Chinese patients with PD . Methods Data from 96 patients with PD were obtained from the Parkinson's disease patient cohort database of Huashan Hospital. All participants underwent a comprehensive neuropsychological evaluation to assess cognitive status, that included scoring on the Mini‐mental state examination ( MMSE ), followed by more detailed cognitive assessment on five main cognitive domains (verbal memory, nonverbal memory, visuospatial function, language and attention/executive function). Correlations between cognitive and motor scores were investigated after controlling for age, disease duration, education, and gender. Results We report a significant correlation between subdomains of cognitive impairment and motor dysfunction using analyses of the multiple linear regression. Notably, executive function and attention was significantly associated with bradykinesia and rigidity, while visuospatial function was associated with bradykinesia and tremor. Conclusions The association between motor dysfunction and cognitive decline in PD might highlight deficits represented by a shared neurochemical pathway.