Open AccessGenetic alterations of IDH 1 and Vegf in brain tumors
Author(s) -
Veganzones Silvia,
Orden Virginia,
Requejo Lucía,
Mediero Beatriz,
González María Luisa,
del Prado Náyade,
Rodríguez García Carmen,
GutiérrezGonzález Raquel,
PérezZamarrón Alvaro,
Martínez Armando,
Maestro Marisa L.,
Zimman Horacio Mario,
GonzálezNeira Anna,
Vaquero Jesús,
RodríguezBoto Gregorio
Publication year - 2017
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.718
Subject(s) - idh1 , isocitrate dehydrogenase , glioma , allele , brain tumor , cancer research , medicine , gene mutation , oncology , mutation , pathology , biology , gene , genetics , biochemistry , enzyme
Background This study evaluates the presence of R132H mutation in isocitrate dehydrogenase ( IDH 1 ) gene and the vascular endothelial growth factor ( VEGF ) +936 C/T polymorphism in brain tumors. The impact of these genetic alterations on overall survival ( OS ) and progression free survival ( PFS ) was evaluated. Methods A cohort of 80 patients surgically treated at Hospital Clínico San Carlos, Madrid, between March 2004 and November 2012, was analyzed. Tumors were distributed in 73 primary brain tumors (gliomas, meningiomas, hemangiopericytomas and hemangioblastomas) and seven secondary tumors evolved from a low grade glioma, thus providing a mixed sample. Results IDH 1 R132H gene mutation was found in 12 patients (15%) and appears more frequently in secondary tumors (5 (71.4%) whereas in 7 (9.7%) primary tumors ( p < .001)). The mutation is related to WHO grade II in primary tumors and a supratentorial location in secondary tumors. The OS analysis for IDH 1 showed a tendency towards a better prognosis of the tumors containing the mutation ( p = .059).The IDH 1 R132H mutation confers a better PFS ( p = .025) on primary tumors. The T allele of VEFG +936 C/T polymorphism was found in 16 patients (20%). No relation was found between this polymorphism and primary or secondary tumor, neither with OS or PFS . Conclusions IDH 1 R132H gene mutation is exclusive in supratentorial tumors and more frequent in secondary ones, with a greater survival trend and better PFS in patients who carry it. The T allele of VEGF +936 C/T polymorphism is more common in primary tumors, although there is no statistical relation with survival.