Open AccessOlfaction in Parkin carriers in Chinese patients with Parkinson disease
Author(s) -
Wang Ying,
Wu JianJun,
Liu FengTao,
Chen Kui,
Chen Chen,
Luo SuShan,
Wang YiXuan,
Li Dake,
Guan RongYuan,
Yang YuJie,
An Yu,
Wang Jian,
Sun YiMin
Publication year - 2017
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.680
Subject(s) - parkin , olfaction , medicine , parkinson's disease , population , confounding , disease , oncology , genetics , psychology , biology , neuroscience , environmental health
Background Olfactory identification was reported to be better among PD (Parkinson disease) patients with Parkin mutations, but previous studies didn't eliminate the interference of other PD related genes on olfaction, and whether olfaction of Parkin mutations patients was better in Chinese population was still unknown. Objective To assess olfaction function among PD patients with Parkin mutations in Chinese population. Materials and Methods A total of 226 PD patients with a positive family history or an early‐onset age (<50 years) were enrolled for genetic testing of PD related genes by target sequencing and multiple ligation‐dependent probe amplification. The clinical data including olfactory function test were investigated. Linear regression was performed to adjust for the covariates between all groups. Results There were 68 patients found having a negative result in PD genetic testing and 43 patients carrying homozygous or compound heterozygous Parkin mutations. Among them, 49 PD panel negative patients and 33 PD ‐ Parkin patients had results of olfactory assessment. PD ‐Parkin patients performed significantly better on the Sniffin’ Sticks tests than panel negative patients (8.0 ± 1.7 vs. 5.7 ± 1.9, p < .001), but still worse compared to healthy controls (9.4 ± 1.5, p = .003). These differences persisted after adjusting for confounders. Conclusions Among Chinese population, PD ‐Parkin patients had relatively preserved olfaction compared to PD panel negative patients after eliminating the interference of other PD related genes, but were still worse than healthy controls.