Open AccessUric acid is associated with vascular dementia in Chinese population
Author(s) -
Xu Yuzhen,
Wang Qian,
Cui Ruiting,
Lu Kaili,
Liu Yunlin,
Zhao Yuwu
Publication year - 2017
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.617
Subject(s) - uric acid , medicine , creatinine , dementia , body mass index , endocrinology , population , cholesterol , vascular dementia , gastroenterology , high density lipoprotein , pathogenesis , blood urea nitrogen , disease , environmental health
Objective Mounting evidence suggests that oxidative stress is involved in the pathogenesis of vascular dementia ( VD ). Uric acid ( UA ) has long been implicated as a critical cause of cardiovascular disease. Nevertheless, UA was also expected to play an important role in antioxidant and neuroprotection recently. We hypothesized that UA may have a protective role against VD . The aim of this study was to investigate the link between serum UA and cognitive dysfunction in VD . Materials and Methods There were altogether 127 VD subjects and 81 nondemented controls enrolled in our study. Serum UA , demographic, and clinical characteristics were recorded at baseline, and all participants underwent Mini‐Mental State Examination ( MMSE ) at the beginning of the trial. Results The VD group showed lower MMSE scores and serum UA levels than nondemented controls and there was significant statistical difference between the two groups ( p < .05). Demographic and clinical characteristics such as age, gender, education, body mass index ( BMI ), total cholesterol ( TC ), triglycerides ( TG ), high‐density lipoprotein cholesterol ( HDL ), low‐density lipoprotein cholesterol ( LDL ), blood urea nitrogen ( BUN ), and serum creatinine (Scr) did not differ dramatically between groups ( p > .05). In VD subjects, there was a positive correlation between serum UA and MMSE scores ( r = .32, p < .05), and this correlation was independent of demographic and clinical characteristics (β = .272, p < .05). Conclusions VD subjects have dramatically lower serum UA levels in comparison to nondemented controls. Lower serum UA levels are linked to cognitive dysfunction and could serve as a potential predictor for VD .