Open AccessWeight loss in the early stage of progressive supranuclear palsy
Author(s) -
Tsuge Ayako,
Kaneko Satoshi,
Wate Reika,
Oki Mitsuaki,
Nagashima Masato,
Asayama Shinya,
Nakamura Masataka,
Fujita Kengo,
Saito Akemi,
Takenouchi Norihiro,
Kusaka Hirofumi
Publication year - 2017
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.616
Subject(s) - progressive supranuclear palsy , weight loss , stage (stratigraphy) , appetite , parkinson's disease , medicine , disease , weight gain , body mass index , pediatrics , body weight , obesity , biology , paleontology
Objectives To clarify whether weight change in patients with Parkinson's disease ( PD ) or progressive supranuclear palsy ( PSP ) is caused by the disease itself or secondarily by other factors. Materials and Methods We conducted a retrospective analysis of 51 patients with PD and 14 patients with PSP , especially during the early stage of their diseases. All patients were independent in terms of their activities of daily living and did not have any feeding difficulty. Results The body mass index measured within 3 years after the disease onset did not show a significant difference between the two diseases. However, the subsequent weight was stable in patients with PD and significantly decreased in patients with PSP . Conclusions Weight loss begins in the early stage of PSP , whereas dopaminergic treatment may contribute to keep weight in the early stage of PD through reduction of energy expenditure and/or improvement in appetite.