Open AccessAltered local spontaneous activity in frontal lobe epilepsy: a resting‐state functional magnetic resonance imaging study
Author(s) -
Dong Li,
Li Hechun,
He Zhongqiong,
Jiang Sisi,
KlugahBrown Benjamin,
Chen Lin,
Wang Pu,
Tan Song,
Luo Cheng,
Yao Dezhong
Publication year - 2016
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.555
Subject(s) - epilepsy , frontal lobe , basal ganglia , neuroscience , magnetic resonance imaging , temporal lobe , functional magnetic resonance imaging , medicine , abnormality , resting state fmri , basal (medicine) , psychology , central nervous system , psychiatry , radiology , insulin
Purpose The purpose of this study was to investigate the local spatiotemporal consistency of spontaneous brain activity in patients with frontal lobe epilepsy ( FLE ). Method Eyes closed resting‐state functional magnetic resonance imaging ( fMRI ) data were collected from 19 FLE patients and 19 age‐ and gender‐matched healthy controls. A novel measure, named FO ur‐dimensional (spatiotemporal) Consistency of local neural Activities ( FOCA ) was used to assess the spatiotemporal consistency of local spontaneous activity (emphasizing both local temporal homogeneity and regional stability of brain activity states). Then, two‐sample t test was performed to detect the FOCA differences between two groups. Partial correlations between the FOCA values and durations of epilepsy were further analyzed. Key Findings Compared with controls, FLE patients demonstrated increased FOCA in distant brain regions including the frontal and parietal cortices, as well as the basal ganglia. The decreased FOCA was located in the temporal cortex, posterior default model regions, and cerebellum. In addition, the FOCA measure was linked to the duration of epilepsy in basal ganglia. Significance Our study suggested that alterations of local spontaneous activity in frontoparietal cortex and basal ganglia was associated with the pathophysiology of FLE ; and the abnormality in frontal and default model regions might account for the potential cognitive impairment in FLE . We also presumed that the FOCA measure had potential to provide important insights into understanding epilepsy such as FLE .