Open AccessPolymorphisms in three genes are associated with hemorrhagic stroke
Author(s) -
Liu Wenpeng,
Ge Shichao,
Liu Yan,
Wei Can,
Ding Yunlong,
Chen Aimin,
Wu Qiyao,
Zhang Yuqing
Publication year - 2015
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.395
Subject(s) - single nucleotide polymorphism , odds ratio , medicine , genotype , genotyping , allele , rage (emotion) , minor allele frequency , confidence interval , population , gastroenterology , stroke (engine) , gene , immunology , genetics , biology , mechanical engineering , environmental health , neuroscience , engineering
Background Multiligand receptor for advanced glycation end products ( RAGE ), osteoprotegerin, and Golgb1 genes may be implicated in atherosclerosis and vascular diseases. Single nucleotide polymorphisms (SNPs) rs1035798 in RAGE gene, rs2073617 and rs2073618 in TNFRSF11B , and rs3732410 in Golgb1 will be investigated on whether there is an association with hemorrhagic stroke ( HS ) in Chinese population. Methods A total of 600 subjects including 199 HS patients and 401 controls were assayed. These samples were divided into two groups: the ≤50 year and >50 year groups. Genotyping of SNP s was determined using the SEQUENOM Mass ARRAY matrix‐assisted laser desorption ionization–time‐of‐flight–mass spectrometry. The association between genotype and HS risk was evaluated by computing the odds ratio ( OR ) and 95% confidence interval ( CI ) with multivariate unconditional logistic regression analyses. Results Our data showed that in the ≤50 year group, the rs1035798 major allele homozygote C/C in RAGE gene was associated with an increased risk of HS , while Golgb1 rs3732410 minor allele homozygote G/G was associated with a decreased risk of HS . In the >50 year group, the major allele homozygote G/G of rs2073618 was found to be associated with an increased risk of HS . Conclusions The polymorphisms rs1035798 of RAGE gene, rs2073618 of TNFRSF11B , and rs3732410 of Golgb1 might be involved in the risk of HS at different stage of ages.