Open AccessPolymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder
Author(s) -
Traks Tanel,
Koido Kati,
Balõtšev Roman,
Eller Triin,
Kõks Sulev,
Maron Eduard,
Tõru Innar,
Shlik Jakov,
Vasar Eero,
Vasar Veiko
Publication year - 2015
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.314
Subject(s) - panic disorder , snp , major depressive disorder , anxiety , mood disorders , biology , genetics , mood , clinical psychology , psychiatry , single nucleotide polymorphism , medicine , gene , genotype
Background The immune system has been increasingly implicated in the development of mood and anxiety disorders. Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon ( IKBKE ) gene encodes IKK ε protein that is involved in innate immunity, predominantly antiviral response generation. It also bears pro‐inflammatory properties that could affect psychiatric outcomes. In order to investigate the possible role of IKBKE gene in major depressive disorder ( MDD ) and panic disorder ( PD ), we conducted a case–control genetic association study concerning these disorders. Methods In all, 14 SNP s of IKBKE gene were genotyped in groups of 391 patients with MDD and 190 patients with PD together with respective 389 and 371 healthy control individuals. The given groups were further divided by gender for additional analyses. Results Substantial genetic associations were revealed between IKBKE SNP s and MDD (multiple testing adjusted P < 0.05) and suggestive associations in case of PD ( P adj > 0.05). In addition, two SNP s that were only associated with PD among males, also displayed significantly different allele frequencies compared to PD females. This may indicate a specific role of these SNP s in male PD , but caution should be applied here due to the small size of the studied PD males group. Conclusions The results of this study confirm our initial findings and indicate a possible role of IKBKE gene in mood and anxiety disorders.