Open AccessIntravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS : a case report
Author(s) -
Uehara Ryuji,
Yamashita Koji,
Hiwatashi Akio,
Togao Osamu,
Kikuchi Kazufumi,
Yokoyama Jun,
Matsuse Dai,
Yoshiura Takashi,
Honda Hiroshi
Publication year - 2014
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.282
Subject(s) - magnetic resonance imaging , phase (matter) , nuclear magnetic resonance , physics , motion (physics) , medicine , radiology , classical mechanics , quantum mechanics
Objective We report the clinical application of intravoxel incoherent motion ( IVIM ) magnetic resonance ( MR ) imaging to diagnose a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke‐like episodes ( MELAS ) in the acute phase. Results On IVIM MR Images of this patient, higher perfusion (f) and diffusion (D) values in the left occipital and temporal lobes were found compared to the contralateral areas. Conclusion These findings imply a breakdown of autoregulation with hyperperfusion and vasogenic edema during the acute phase of MELAS , as described in previous reports. IVIM imaging is a valuable, noninvasive tool that simultaneously quantifies perfusion and diffusion parameters.