Open AccessCancer‐related stroke: Exploring personalized therapy strategies
Author(s) -
Chen YuJie,
Dong RuiGuo,
Zhang MengMeng,
Sheng Chao,
Guo PengFei,
Sun Jie
Publication year - 2022
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.2738
Subject(s) - medicine , stroke (engine) , disease , cancer , incidence (geometry) , intensive care medicine , life expectancy , cause of death , concomitant , physical therapy , population , mechanical engineering , physics , environmental health , optics , engineering
Background Cancer and ischemic stroke are two common diseases that threaten human health and have become the main causes of death in the world. It is estimated that one‐in‐ten patients with ischemic stroke have concomitant cancer, and this incidence is expected to increase as improvements in medical technology extends the life expectancy of cancer patients. Discussion Cancer‐related stroke (CRS) refers to unexplained ischemic stroke in patients with active cancer that cannot be explained by current stroke mechanisms. Available evidence suggests that CRS accounts for 5–10% of embolic stroke of undetermined source (ESUS). Although the incidence of CRS is gradually increasing, its underlying pathogenesis remains unclear. Also, there is no consensus on acute treatment and secondary prevention of stroke. Conclusion In this review, we retrospectively analyzed the incidence, mechanisms of CRS, its potential as a new stroke subtype, options for acute treatment, secondary prevention strategies, and disease progression, with the aim of attempting to explore personalized therapy strategies.