Open AccessThe combination of living Bifidobacterium, Lactobacillus , and Streptococcus improves social ranking and relieves anxiety‐like behaviors in competitive mice in a social dominance tube test
Author(s) -
Xie Jianping,
Yuan Yun,
Tan Heng,
Bai Yufan,
Zheng Qingyue,
Mao Lin,
Wu Yushan,
Wang Ling,
Da Wenhui,
Ye Qingyan,
Zhang Suting,
Wang Jing,
Yin Wenyao,
Bian Yujing,
Ma Wenjie,
Zhang Lanchun,
Zhang Rongping,
Yu Haofei,
Guo Ying
Publication year - 2022
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.2453
Subject(s) - bifidobacterium , gut flora , anxiety , streptococcus , lactobacillus , tumor necrosis factor alpha , social anxiety , brain derived neurotrophic factor , psychology , neurotrophic factors , microbiology and biotechnology , biology , immunology , medicine , bacteria , psychiatry , food science , fermentation , genetics , receptor
Social rank has a profound influence on the behavior and health of humans and animals. Methods To explore the effect of a combination of living Bifidobacterium, Lactobacillus and Streptococcus (CLB) on anxiety‐ and depression‐like behaviors and social rank, mice were subjected to a social dominance tube test (SDTT). The behaviors, rank, gut microbiota, and expression of inflammatory cytokines and brain‐derived neurotrophic factor (BDNF) in the hippocampus were measured. Results The results indicated that CLB improved the SDTT ranking score of the losers and alleviated anxiety‐like behaviors of the winners. CLB decreased the level of Desulfovibrio and augmented the level of Mollicutes in the feces, increased BDNF content, and reduced the level of tumor necrosis factor‐α in the hippocampus. Conclusion These findings indicated that CLB may be used for the treatment of anxiety and improvement of the rank score via regulation of gut microbiota and anti‐inflammatory effects.