Open AccessAssessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis
Author(s) -
CollMartinez Clàudia,
Quintana Ester,
SalavedraPont Judit,
Buxó Maria,
GonzálezdelRio Marina,
Gómez Immaculada,
MuñozSan Martín María,
Villar Luisa María,
ÁlvarezBravo Gary,
RoblesCedeño René,
RamióTorrentà Lluís,
Gich Jordi
Publication year - 2021
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.2405
Subject(s) - multiple sclerosis , biomarker , neuropsychology , cerebrospinal fluid , medicine , depression (economics) , oncology , neuropsychological assessment , cognitive decline , cognition , gastroenterology , psychology , immunology , psychiatry , dementia , disease , biology , biochemistry , macroeconomics , economics
Background An association has been found between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. Objective To investigate lipid‐specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairment in the early stages of multiple sclerosis. Methods Forty‐four patients underwent neuropsychological assessment at baseline and 4 years. Cognitive performance at follow‐up was compared adjusting by age, education, anxiety–depression, and baseline performance. Results LS‐OCMB+ patients only performed worse for Long‐Term Storage in the Selective Reminding Test ( p = .018). Conclusion There are no remarkable cognitive differences between LS‐OCMB– and LS‐OCMB+ patients in the early stages of MS.