Open AccessPsychosocial factors and cancer incidence (PSY‐CA): Protocol for individual participant data meta‐analyses
Author(s) -
Tuijl Lonneke A.,
Voogd Adri C.,
Graeff Alexander,
Hoogendoorn Adriaan W.,
Ranchor Adelita V.,
Pan KuanYu,
Basten Maartje,
Lamers Femke,
Geerlings Mirjam I.,
Abell Jessica G.,
Awadalla Philip,
Bakker Marije F.,
Beekman Aartjan T. F.,
Bjerkeset Ottar,
Boyd Andy,
Cui Yunsong,
Galenkamp Henrike,
Garssen Bert,
Hellingman Sean,
Huisman Martijn,
Huss Anke,
Keats Melanie R.,
Kok Almar A. L.,
Luik Annemarie I.,
Noisel Nolwenn,
OnlandMoret N. Charlotte,
Payette Yves,
Penninx Brenda W. J. H.,
Portengen Lützen,
Rissanen Ina,
Roest Annelieke M.,
Rosmalen Judith G. M.,
Ruiter Rikje,
Schoevers Robert A.,
Soave David M.,
Spaan Mandy,
Steptoe Andrew,
Stronks Karien,
Sund Erik R.,
Sweeney Ellen,
Teyhan Alison,
Vaartjes Ilonca,
Willik Kimberly D.,
Leeuwen Flora E.,
Petersen Rutger,
Verschuren W. M. Monique,
Visseren Frank,
Vermeulen Roel,
Dekker Joost
Publication year - 2021
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.2340
Subject(s) - psychosocial , medicine , anxiety , clinical psychology , alcohol use disorders identification test , breast cancer , cancer , psychology , psychiatry , environmental health , poison control , injury prevention
Objectives Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking‐related, and alcohol‐related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods The psychosocial factors and cancer incidence (PSY‐CA) consortium was established involving experts in the field of (psycho‐)oncology, methodology, and epidemiology. Using data collected in 18 cohorts ( N = 617,355), a preplanned two‐stage individual participant data (IPD) meta‐analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta‐analyses will be performed on the risk estimates (stage 2). Conclusion PSY‐CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta‐analyses.