Open AccessMeasuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: Comparison in younger and older adults
Author(s) -
Burley Claire V.,
Francis Susan T.,
Whittaker Anna C.,
Mullinger Karen J.,
Lucas Samuel J.E.
Publication year - 2021
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.2126
Subject(s) - cerebral blood flow , medicine , transcranial doppler , magnetic resonance imaging , cardiology , perfusion scanning , perfusion , cerebral perfusion pressure , middle cerebral artery , hemodynamics , cohort , resting state fmri , radiology , ischemia
Resting cerebral blood flow (CBF) and perfusion measures have been used to determine brain health. Studies showing variation in resting CBF with age and fitness level using different imaging approaches have produced mixed findings. We assess the degree to which resting CBF measures through transcranial Doppler (TCD) and arterial spin labeling (ASL) MRI provide complementary information in older and younger, fit and unfit cohorts. Methods Thirty‐five healthy volunteers (20 younger: 24 ± 7y; 15 older: 66 ± 7y) completed two experimental sessions (TCD/MRI). Aging and fitness effects within and between imaging modalities were assessed. Results Middle cerebral artery blood velocity (MCAv, TCD) was lower and transit time (MRI) slower in older compared with younger participants ( p < .05). The younger group had higher gray matter cerebral perfusion (MRI) than the older group, albeit not significantly ( p = .13). Surprisingly, fitness effects in the younger group (decrease/increase in MCAv/transit time with fitness, respectively) opposed the older group (increase/decrease in MCAv/transit time). Whole cohort transit times correlated with MCAv (r=−0.63; p < .05), whereas tissue perfusion did not correlate with TCD measures. Conclusion TCD and MRI modalities provide complementary resting CBF measures, with similar effects across the whole cohort and between subgroups (age/fitness) if metrics are comparable (e.g., velocity [TCD] versus transit time [MRI]).