Open AccessNono‐titanium dioxide exposure during the adolescent period induces neurotoxicities in rats: Ameliorative potential of bergamot essential oil
Author(s) -
Cui Yonghua,
Che Yi,
Wang Hongxin
Publication year - 2021
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.2099
Subject(s) - neuroinflammation , oxidative stress , elevated plus maze , hippocampus , neuroprotection , antioxidant , pharmacology , chemistry , medicine , anxiety , inflammation , biochemistry , psychiatry
In adolescence, the brain is still maturing, and disorders in maturation may affect the normal development of the brain. Exposure to titanium dioxide nanoparticles (TiO 2 NPs) has various potential negative effects on the central nervous system. Bergamot essential oil (BEO) has been found to be effective for neuroprotection. Methods The rats were injected intraperitoneally with TiO 2 NPs (20 mg/kg) and/or BEO (200 mg/kg). The endogenous antioxidant state and inflammatory parameters were estimated using ELISA kits, and then the memory ability and anxiety‐like behavior in rats were assessed. Results TiO 2 NPs exposure during the adolescent period induced anxiety‐like behavior, cognitive impairment, neuroinflammation and oxidative damage in hippocampus, and BEO treatment could significantly ameliorate the neurotoxicities induced by TiO 2 NPs exposure. Conclusion Our results suggest that the negative effects of TiO 2 NPs exposure during the adolescent period on anxiety‐like behavior and cognitive function may be related to oxidative stress and neuroinflammation induced by TiO 2 NPs exposure. In addition, BEO may ameliorate the neurotoxicities induced by TiO2 NPs exposure in adolescent rats through the antioxidant and anti‐inflammatory activity of BEO.