Open AccessThe role of FGF 2 in spinal cord trauma and regeneration research
Author(s) -
Adeeb Nimer,
Mortazavi Martin M.
Publication year - 2014
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.207
Subject(s) - neuroscience , gliosis , neurite , spinal cord injury , central nervous system , progenitor cell , spinal cord , regeneration (biology) , axon , fibroblast growth factor , glial scar , neural stem cell , medicine , neuroinflammation , biology , inflammation , immunology , stem cell , microbiology and biotechnology , biochemistry , in vitro , receptor
We read with interest the article by Goldshmit et al. in this issue of Brain and Behavior . They hypothesized that FGF2 , given subcutaneously in a hemisection spinal cord injury ( SCI ) model in mice, decreases inflammation and gliosis, increases radial glia, neural progenitor cells, neuronal survival and axonogenesis, and ultimately leads to improved functional recovery.