Open AccessElectrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures
Author(s) -
Santos George Francisco S.,
Ferreira Luan Oliveira,
Gerrits Mattos Bruna,
Fidelis Eliniete J.,
Souza Alisson S.,
Batista Paula S.,
Manoel Cecilia A. F.,
Cabral Diego Arthur C.,
Jóia de Mello Vanessa,
Favacho Lopes Dielly Catrina,
Hamoy Moisés
Publication year - 2021
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.1940
Subject(s) - status epilepticus , anticonvulsant , diazepam , lidocaine , medicine , epilepsy , anticonvulsant drugs , anesthesia , electroencephalography , toxicity , convulsion , pharmacology , psychiatry
Local anesthetics are widely used in clinical practice. While toxicity is rare, these drugs can cause potentially lethal seizures. Objective In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs. The study used adult male Wistar rats to describe of the seizure‐related behavior of LA and investigated the treatment with anticonvulsant drugs. Results The use of LA resulted in clear changes in the ECoG pattern, which presented characteristics of Status epilepticus , with increased intensity in all brainwaves. The decomposition of the cerebral waves showed an increase in the beta and gamma waves that may be related to tonic–clonic seizure. Although the treatment with anticonvulsants drugs reduces the power of brainwaves at frequencies between 1 and 40 Hz compared to the LA group, but only diazepam (DZP) was able to decrease the intensity of oscillations. The muscle contraction power also indicated a difference in the effectiveness of the three treatments. Conclusion The sum of the evidence indicates that LA causes status epilepticus and that DZP is the most effective treatment for the control of these seizures, by restoring the systemic values to levels close to those recorded in the control group.