Open AccessLeft ventricular ejection fraction as an independent predictor of poor outcome in acute intracerebral hemorrhage
Author(s) -
Yang Guang,
Wang Lu,
Sun Jingxian,
Zhang Daming,
Zhang Ruotian,
Yuan Chao,
Long Meixin,
Zhong Yingqiang,
Li Chunmei,
Wang Xiaoxiong,
Chen Xin,
Zhou Qi,
Liu Bo,
Jiang Hongquan,
Lian Ailing,
Gareev Ilgiz,
Li Lili,
Zhao Shiguang
Publication year - 2020
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.1643
Subject(s) - medicine , ejection fraction , odds ratio , modified rankin scale , intracerebral hemorrhage , logistic regression , confidence interval , cardiology , retrospective cohort study , univariate analysis , heart failure , multivariate analysis , subarachnoid hemorrhage , ischemic stroke , ischemia
Few studies of the effect of cardiac abnormalities on acute intracerebral hemorrhage (ICH) outcomes have been published. We sought to determine whether the left ventricular ejection fraction (LVEF) is associated with the functional outcome and mortality of acute ICH patients. Methods We conducted a retrospective study on 364 acute ICH patients from January to December 2016. The primary outcome was defined by the modified Rankin Scale and mortality at 3 months. The associations between LVEF and outcome were investigated using univariable and multivariable logistic regression models. Results Depressed LVEF was significantly associated with a poor functional outcome with an odds ratio [OR] of 0.966, 95% confidence interval (CI) 0.942–0.991, p = .008, and high mortality (OR 0.968 [95% CI 0.943–0.994], p = .015) at 3 months for acute ICH patients by univariate analysis. Multivariable logistic regression analysis indicated that LVEF was an independent predictor of a poor functional outcome (OR 0.961 [95% CI 0.935–0.988], p = .005) and mortality (OR 0.949 [95% CI 0.918–0.981], p = .002). The percentage of acute ICH patients with poor functional outcome ( p = .005) and mortality ( p = .002) was obviously higher in the group of patients with a LVEF of <50%. Conclusions LVEF is an independent predictor of functional outcome and mortality at 3 months for acute ICH patients. These findings could provide the evidence needed for prognosis prediction in acute ICH patients.