Open AccessThe correlation between serum apolipoprotein B/apolipoprotein A1 ratio and brain necrosis in patients underwent radiotherapy for nasopharyngeal carcinoma
Author(s) -
Li Honghong,
Zheng Dong,
Xie Fukang,
Huang Xiaolong,
Zhuo Xiaohuang,
Lin Jinpeng,
Li Yi,
Tang Yamei
Publication year - 2020
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.1554
Subject(s) - apolipoprotein b , medicine , nasopharyngeal carcinoma , radiation therapy , apolipoprotein a1 , gastroenterology , magnetic resonance imaging , endocrinology , oncology , pathology , cholesterol , radiology
The apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio is recognized as a clinical indicator of cardiovascular disease and ischemic cerebral disease. Cerebrovascular dysfunction is also involved in head and neck radiotherapy. The aim of this study was to investigate the correlation between ApoB/ApoA1 ratio and the severity of radiation‐induced brain necrosis (RN) in patients who underwent radiotherapy after nasopharyngeal carcinoma (NPC). Methods In this retrospective study, 191 NPC patients diagnosed with RN were evaluated. Clinical characteristics, serum lipid, apolipoproteins, and brain magnetic resonance imaging findings were collected. Serum lipid and apolipoproteins were quantified using standard diagnostic assays, and the quality of life (QOL) was assessed by the World Health Organization quality of life abbreviated instrument (WHOQOL‐BREF). Results ApoB/ApoA1 ratio was positively correlated with lesion volume ( r = .18, p = .03) and negatively correlated with WHOQOL‐BREF scores ( r = −.28, p < .01). The ApoB/ApoA1 ratio and intensity‐modulated radiation therapy (IMRT) were independent risk factor of RN volume. Moreover, ApoB/ApoA1 ratio was significantly negatively correlated with physical health ( r = −.29, p < .01), psychological ( r = −.27, p < .01), social relationships ( r = −.17, p = .02), and environment ( r = −.27, p < .01) domains of WHOQOL‐BREF. Conclusions Serum ApoB/ApoA1 ratio is positively correlated with RN volume, which indicated serum ApoB/ApoA1 ratio as an independent risk factor for lesion volume in patients with RN after radiotherapy for NPC, suggesting a bright intervention target in RN treatment.