Open AccessEarly and very early‐onset schizophrenia compared with adult‐onset schizophrenia: French FACE‐SZ database
Author(s) -
Coulon Nathalie,
Godin Ophélia,
Bulzacka Ewa,
Dubertret Caroline,
Mallet Jasmina,
Fond Guillaume,
Brunel Lore,
Andrianarisoa Méja,
Anderson George,
Chereau Isabelle,
Denizot Hélène,
Rey Romain,
Dorey JeanMichel,
Lançon Christophe,
Faget Catherine,
Roux Paul,
Passerieux Christine,
Dubreucq Julien,
Leignier Sylvain,
Capdevielle Delphine,
André Myrtille,
Aouizerate Bruno,
Misdrahi David,
Berna Fabrice,
Vidailhet Pierre,
Leboyer Marion,
Schürhoff Franck
Publication year - 2020
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.1495
Subject(s) - schizophrenia (object oriented programming) , dup , neuropsychology , age of onset , psychiatry , pediatrics , psychosis , psychology , positive and negative syndrome scale , medicine , clinical psychology , disease , cognition , biochemistry , chemistry , gene duplication , gene
Objective To compare the clinical symptomatology in patients with Early‐Onset Schizophrenia (EOS, N = 176), especially the subgroup Very Early Onset Schizophrenia (VEOS) and Adult Onset Schizophrenia (AOS, N = 551). Method In a large French multicentric sample, 727 stable schizophrenia patients, classified by age at onset of the disorder, were assessed using standardized and extensive clinical and neuropsychological batteries: AOS with onset ≥ 18 years and EOS with onset < 18 years (including 22 VEOS < 13 years). Results The importance of better diagnosing EOS group, and in particularly VEOS, appeared in a longer DUP Duration of Untreated Psychosis (respectively, 2.6 years ± 4.1 and 8.1 years ± 5.7 vs. 1.0 years ± 2.5), more severe symptomatology (PANSS Positive And Negative Syndrome Scale scores), and lower educational level than the AOS group. In addition, the VEOS subgroup had a more frequent childhood history of learning disabilities and lower prevalence of right‐handedness quotient than the AOS. Conclusion The study demonstrates the existence of an increased gradient of clinical severity from AOS to VEOS. In order to improve the prognosis of the early forms of schizophrenia and to reduce the DUP, clinicians need to pay attention to the prodromal manifestations of the disease.