Open AccessReconfiguration of large‐scale functional connectivity in patients with disorders of consciousness
Author(s) -
Martínez Darwin E.,
Rudas Jorge,
Demertzi Athena,
CharlandVerville Vanessa,
Soddu Andrea,
Laureys Steven,
Gómez Francisco
Publication year - 2020
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.1476
Subject(s) - neuroscience , functional connectivity , consciousness , persistent vegetative state , resting state fmri , centrality , psychology , default mode network , functional integration , brain mapping , betweenness centrality , functional magnetic resonance imaging , minimally conscious state , mathematical analysis , mathematics , combinatorics , integral equation
Functional connectivity alterations within individual resting state networks (RSNs) are linked to disorders of consciousness (DOC). If these alterations influence the interaction quality with other RNSs, then, brain alterations in patients with DOC would be characterized by connectivity changes in the large‐scale model composed of RSNs. How are functional interactions between RSNs influenced by internal alterations of individual RSNs? Do the functional alterations induced by DOC change some key properties of the large‐scale network, which have been suggested to be critical for the consciousness emergence? Here, we use network analysis to measure functional connectivity in patients with DOC and address these questions. We hypothesized that network properties provide descriptions of brain functional reconfiguration associated with consciousness alterations. Methods We apply nodal and global network measurements to study the reconfiguration linked with the disease severity. We study changes in integration, segregation, and centrality properties of the functional connectivity between the RSNs in subjects with different levels of consciousness. Results Our analysis indicates that nodal measurements are more sensitive to disease severity than global measurements, particularly, for functional connectivity of sensory and cognitively related RSNs. Conclusion The network property alterations of functional connectivity in different consciousness levels suggest a whole‐brain topological reorganization of the large‐scale functional connectivity in patients with DOC.