Open AccessIntermittent fasting increases adult hippocampal neurogenesis
Author(s) -
Baik SangHa,
Rajeev Vismitha,
Fann David YangWei,
Jo DongGyu,
Arumugam Thiruma V.
Publication year - 2020
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.1444
Subject(s) - neurogenesis , creb , hippocampal formation , long term potentiation , neuroscience , brain derived neurotrophic factor , notch signaling pathway , hippocampus , neuroprotection , biology , neurotrophic factors , nestin , endocrinology , medicine , transcription factor , neural stem cell , microbiology and biotechnology , signal transduction , stem cell , receptor , biochemistry , gene
Abstract Introduction Intermittent fasting (IF) has been suggested to have neuroprotective effects through the activation of multiple signaling pathways. Rodents fasted intermittently exhibit enhanced hippocampal neurogenesis and long‐term potentiation (LTP) at hippocampal synapses compared with sedentary animals fed an ad libitum (AL) diet. However, the underlying mechanisms have not been studied. In this study, we evaluated the mechanistic gap in understanding IF‐induced neurogenesis. Methods We evaluated the impact of 3 months of IF (12, 16, and 24 hr of food deprivation on a daily basis) on hippocampal neurogenesis in C57BL/6NTac mice using immunoblot analysis. Results Three‐month IF significantly increased activation of the Notch signaling pathway (Notch 1, NICD1, and HES5), neurotrophic factor BDNF, and downstream cellular transcription factor, cAMP response element‐binding protein (p‐CREB). The expression of postsynaptic marker, PSD95, and neuronal stem cell marker, Nestin, was also increased in the hippocampus in response to 3‐month IF. Conclusions These findings suggest that IF may increase hippocampal neurogenesis involving the Notch 1 pathway.