z-logo
open-access-imgOpen Access
Perfusion 123 IMP‐SPECT shows reversible abnormalities in GABA B receptor antibody associated encephalitis with normal MRI
Author(s) -
Ohta Kouichi,
Seki Morinobu,
Dalmau Josep,
Shinohara Yukito
Publication year - 2011
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.14
Subject(s) - perfusion , antibody , receptor , medicine , encephalitis , nuclear medicine , pathology , immunology , virus
A new subtype of autoimmune encephalitis associated with antibodies against GABA B receptor was recently identified. Although immune‐mediated functional abnormalities are suggested for the pathogenesis, functional brain imaging such as perfusion SPECT has not been documented. A 62‐year‐old woman with anti‐GABA B receptor associated encephalitis underwent 123 I‐IMP SPECT in the beginning and after methylprednisolone pulse therapy. Three‐dimensional stereotactic surface projection analysis was used to evaluate the cortical distribution of perfusion abnormality. The patient presented with clinical features of subacute limbic encephalitis. Antibodies to GABA B receptor were identified in her serum and cerebrospinal fluid (CSF), but no tumor was detected. Despite normal magnetic resonance imaging (MRI) findings, the first SPECT revealed hypoperfusion of the frontal, parietal and medial temporal lobes, as well as thalamus, and cerebellum. These areas are known to contain high levels of GABA B receptors. In contrast, the SPECT revealed hyperperfusion in the motor strip and left temporal lobe, which are areas related to some of the patient's symptoms, including seizures, orolingual dyskinesia, and Wernicke aphasia. After treatment with pulses of methylprednisolone, the neuropsychiatric symptoms resolved and the SPECT findings showed substantial improvement in most of these regions. In conclusion, the findings suggest that immunotherapy improved the cortical dysfunction mediated by GABA B receptor antibodies.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here