Open AccessPilot data on telmisartan short‐term effects on glucose metabolism in the olfactory tract in Alzheimer's disease
Author(s) -
Imabayashi Etsuko,
Matsuda Hiroshi,
Yoshimaru Kimiko,
Kuji Ichiei,
Seto Akira,
Shimano Yasumasa,
Ito Kimiteru,
Kikuta Daisuke,
Shimazu Tomokazu,
Araki Nobuo
Publication year - 2011
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.13
Subject(s) - telmisartan , anterior olfactory nucleus , medicine , olfactory system , endocrinology , carbohydrate metabolism , positron emission tomography , fluorodeoxyglucose , olfactory bulb , nuclear medicine , central nervous system , olfactory tubercle , blood pressure , psychiatry
The possible effect of antihypertensive therapy on Alzheimer's disease (AD) has been studied, and angiotensin II receptor blockers (ARBs) have been suggested to exert an effect on cognitive decline. The purpose of this study is to clarify the functional effects of telmisartan, a long‐acting ARB, on AD brain using prospective longitudinal 18 F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) studies. For this purpose, brain glucose metabolism of four hypertensive patients with AD was examined with FDG‐PET before and after administration of telmisartan. Studied subjects underwent three FDG‐PET studies at intervals of 12 weeks. Antihypertensive treatment except for telmisartan was started after the first FDG‐PET and continued for 24 weeks. Then 40–80 mg of telmisartan was added after the second FDG‐PET and continued for 12 weeks.Glucose metabolism was significantly decreased during the first 12 weeks without telmisartan use at an area (−10, 21, −22, x, y, z; Z = 3.56) caudal to the left rectal gyrus and the olfactory sulcus corresponding to the left olfactory tract. In contrast, the introduction of telmisartan during the following 12 weeks preserved glucose metabolism at areas (5, 19, −20, x, y, z; Z = 3.09; 6, 19, −22, x, y, z; Z = 2.88) caudal to the bilateral rectal gyri and olfactory sulci corresponding to the bilateral olfactory tracts. No areas showed decreased glucose metabolism after the introduction of telmisartan. In AD, amyloid‐β deposition is observed in the anterior olfactory nucleus (AON) of the olfactory tract. Glucose metabolism in AON may be progressively decreased and preserved by telmisartan.