Open AccessCircle of Willis variations in migraine patients with ischemic stroke
Author(s) -
Hamming Arend M.,
van Walderveen Marianne A. A.,
Mulder Inge A.,
van der Schaaf Irene C.,
Kappelle L. Jaap,
Velthuis Birgitta K.,
Ferrari Michel D.,
Terwindt Gisela M.,
Visser Marieke C.,
Schonewille Wouter,
Algra Ale,
Wermer Marieke J. H.
Publication year - 2019
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.1223
Subject(s) - migraine , medicine , aura , circle of willis , stroke (engine) , posterior communicating artery , odds ratio , anterior communicating artery , logistic regression , anterior cerebral artery , middle cerebral artery , cardiology , subarachnoid hemorrhage , ischemia , internal carotid artery , mechanical engineering , engineering
Abstract Objectives Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine. Materials and Methods Participants were recruited from the prospective Dutch acute Stroke Study. All participants underwent CT angiography on admission. Lifetime migraine history was assessed with a screening questionnaire and confirmed by an interview based on International Classification of Headache Disorders criteria. The CoW was assessed for incompleteness/hypoplasia (any segment <1 mm), for anterior cerebral artery asymmetry (difference > 1/3), and for posterior communicating artery (Pcom) dominance (Pcom–P1 difference > 1/3). Odds ratios with adjustments for age and sex ( aOR ) were calculated with logistic regression. Results We included 646 participants with stroke, of whom 52 had a history of migraine. Of these, 45 (87%) had an incomplete or hypoplastic CoW versus 506 (85%) of the 594 participants without migraine ( aOR : 1.47; 95% CI : 0.63–3.44). There were no differences between participants with and without migraine in variations of the anterior or posterior CoW, anterior cerebral artery asymmetry ( aOR : 0.86; 95% CI : 0.43–1.74), or Pcom dominance ( aOR : 0.64; 95% CI : 0.32–1.30). There were no differences in CoW variations between migraine patients with or without aura. Conclusion We found no significant difference in the completeness of the CoW in acute stroke patients with migraine compared to those without.