Open AccessPsychiatric profile of motor subtypes of de novo drug‐naïve Parkinson's disease patients
Author(s) -
Assogna Francesca,
Pellicano Clelia,
Cravello Luca,
Savini Cinzia,
Pierantozzi Mariangela,
Mercuri Bruno,
Caltagirone Carlo,
Pontieri Francesco E.,
Spalletta Gianfranco,
Stefani Alessandro
Publication year - 2018
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.1094
Subject(s) - parkinson's disease , dopaminergic , disease , motor symptoms , drug , drug naïve , medicine , psychiatry , cognition , psychology , dopamine
Background Parkinson's disease ( PD ) is a heterogeneous neurodegenerative disorder. It is well established that different motor subtypes of PD evolve with different clinical courses and prognoses. The complete psychiatric profile underlying these different phenotypes since the very early stage of the disease is debated. Aims of the study We aimed at investigating the psychiatric profile of the three motor subtypes of PD (akinetic‐rigid, tremor‐dominant, and mixed) in de novo drug‐naïve patients with PD . Methods Sixty‐eight patients with PD , divided into 39 akinetic‐rigid ( AR ), seven mixed ( MIX ), and 22 tremor‐dominant ( TD ) patients underwent a complete assessment of psychiatric, cognitive, and motor symptoms. Results No significant differences were found among groups. Conclusions Our results suggest that a differentiation of the psychiatric symptoms associated with specific motor subtypes of PD is not detectable in de novo drug‐naïve patients. Previous evidence that emerges later along the disease progression may be a consequence of the dopaminergic and nondopaminergic damage increase.