Open AccessThe association between “Brain‐Age Score” ( BAS ) and traditional neuropsychological screening tools in Alzheimer's disease
Author(s) -
Beheshti Iman,
Maikusa Norihide,
Matsuda Hiroshi
Publication year - 2018
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.1020
Subject(s) - dementia , alzheimer's disease neuroimaging initiative , atrophy , neuroimaging , white matter , neuropsychology , magnetic resonance imaging , medicine , alzheimer's disease , correlation , cognitive impairment , brain size , neuropsychological assessment , disease , nuclear medicine , cognition , radiology , psychiatry , geometry , mathematics
We present the Brain‐Age Score ( BAS ) as a magnetic resonance imaging ( MRI )‐based index for Alzheimer's disease ( AD ). We developed a fully automated framework for estimating the BAS in healthy controls ( HC s) and individuals with mild cognitive impairment ( MCI ) or AD , using MRI scans. Methods We trained the proposed framework using 385 HC s from the IXI and OASIS datasets and evaluated 146 HC s, 102 stable‐ MCI ( sMCI ), 112 progressive‐ MCI ( pMCI ), and 147 AD patients from the J‐ ADNI dataset. We used a correlation test to determine the association between the BAS and four traditional screening tools of AD : the Mini‐Mental State Examination ( MMSE ), Clinical Dementia Ratio ( CDR ), Alzheimer's Disease Assessment Score ( ADAS ), and Functional Assessment Questionnaire ( FAQ ). Furthermore, we assessed the association between BAS and anatomical MRI measurements: the normalized gray matter ( nGM ), normalized white matter ( nWM ), normalized cerebrospinal fluid ( nCSF ), mean cortical thickness as well as hippocampus volume. Results The correlation results demonstrated that the BAS is in line with traditional screening tools of AD (i.e., the MMSE , CDR , ADAS , and FAQ scores) as well as anatomical MRI measurements (i.e., nGM , nCSF , mean cortical thickness, and hippocampus volume). Discussion The BAS may be useful for diagnosing the brain atrophy level and can be a reliable automated index for clinical applications and neuropsychological screening tools.