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In vitro protein binding interaction studies involving cefixime
Author(s) -
Bialer Meir,
Wu Wen Hui,
Faulkner Robert D.,
Michael Silber B.,
Yacobi Avraham
Publication year - 1988
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bod.2510090309
Subject(s) - cefixime , probenecid , pharmacology , plasma protein binding , in vitro , chemistry , drug interaction , free fraction , drug , medicine , cephalosporin , biochemistry , antibiotics
Cefixime is a new oral cephalosporin currently undergoing clinical trials. Selected agents with the likelihood for coadministration with cefixime in man were examined for their influence on the in vitro binding of cefixime in pooled serum from dog, monkey, and man. Results from these experiments showed no significant change in cerfixime binding in any animal species studied or in man by acetaminophen, heparin, phenytoin, diazepam, ibuprofen or furosemide at their maximum reported therapeutic concentrations. In contrast, both salicylic acid and probenecid resulted in concentration‐dependent increases in the free fraction of cefixime (up to 2.5‐fold). These findings demonstrate the usefulness of in vitro protein binding screening procedures for studying potential drug interactions that are mediated, at least in part, by changes in the protein binding of a drug.