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Influence of a standard meal on the absorption of a controlled release pseudoephedrine suspension
Author(s) -
Graves D. A.,
Wecker M. T.,
Amsel L. P.,
Hinsvark O. N.,
Bhargava A. K.,
Rotenberg K. S.,
Meyer M. C.,
Straughn A. B.
Publication year - 1988
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bod.2510090305
Subject(s) - pseudoephedrine , postprandial , meal , chemistry , absorption (acoustics) , suspension (topology) , ephedrine , chromatography , food science , pharmacology , mathematics , medicine , endocrinology , materials science , composite material , homotopy , insulin , pure mathematics
The influence of a standard meal on the extent and rate of absorption of pseudoephedrine from a liquid controlled release (CR) formulation (Pennkinetic System) was studied in 16 normal male volunteers. Equivalent single doses of an immediate release reference syrup (IR‐Sudafed) and the CR suspension were each studied under both fasted and postprandial conditions. AUC results showed no significant influence of food or formulation, indicating that the CR formulation was absorbed to the same extent as the IR product under all conditions. C MAX and T MAX tabulations under fasted conditions indicated that the CR preparation peaked at a lower level at a later time. Food diminished IR C MAX s but the CR suspension's C MAX s and T MAX s were apparently unaffected by food. This study indicates that this CR pseudoephedrine suspension releases drug independently of food intake.