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Effect of acute water deprivation on renal function in rats
Author(s) -
Prasad P.,
Niazi S.,
Jung D.
Publication year - 1988
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bod.2510090304
Subject(s) - effective renal plasma flow , hippuric acid , renal function , inulin , pah clearance , endocrinology , medicine , dehydration , chemistry , kidney , renal blood flow , urology , biochemistry , urine
The effect of acute water deprivation for 96 h on renal function was studied in male Sprague‐Dawley rats. The glomerular filtration rate (GFR) and the effective renal plasma flow (ERPF) were estimated using inulin and p‐amino hippuric acid (PAH), respectively, as model compounds. Acute water deprivation caused a significant decrease (44 per cent) in the GFR without altering the ERPF. These results indicate that a proper dosage adjustment may have to be made in the dehydration condition, especially for drugs whose disposition is dependent on GFR.