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Pharmacokinetics of 8‐methoxypsoralen in the dog
Author(s) -
Monbaliu J. G.,
Belpaire F. M.,
Braeckman R. A.,
Bogaert M. G.
Publication year - 1988
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bod.2510090103
Subject(s) - pharmacokinetics , oral administration , distribution (mathematics) , pharmacology , medicine , fissipedia , chemistry , anesthesia , mathematical analysis , mathematics
The pharmacokinetics of 8‐MOP were studied in six dogs following intravenous administration of 2 mg kg −1 . In most animals a bi‐exponential decline of the plasma level profile was observed. The calculated pharmacokinetic parameters varied considerably between the different dogs. The mean half‐lives of distribution and of elimination were 0.20 h and 2.17 h, respectively. The average total plasma clearance was 0.51 1 kg −1 h − . Following both oral and intravenous administration of doses of 1, 3, and 10 mg kg −1 , non‐linear kinetics were found. Non‐linearity was confirmed following administration of the substance at increasing infusion rates. Finally in four dogs, extraction by the liver was calculated by measuring 8‐MOP concentration in the femoral artery and in a hepatic vein after intravenous administration of 1 mg kg −1 . The extraction varied from animal to animal (18 per cent to nearly 100 per cent). Administration of an additional dose of 3 mg kg −1 in two of the dogs led to a decreased extraction.