Premium
On‐capillary isotachophoresis for loadability enhancement in capillary zone electrophoresis/mass spectrometry of β‐agonists
Author(s) -
Lamoree M. H.,
Reinhoud N. J.,
Tjaden U. R.,
Niessen W. M. A.,
van der Greef J.
Publication year - 1994
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200230607
Subject(s) - isotachophoresis , capillary electrophoresis , chromatography , chemistry , capillary electrophoresis–mass spectrometry , capillary action , mass spectrometry , electrophoresis , quantitative analysis (chemistry) , detection limit , electrospray ionization , materials science , electrolyte , electrode , composite material
For the enhancement of sample loadability and concentration sensitivity in capillary zone electrophoresis/mass spectrometry (CZE/MS) on‐line isotachophoresis/capillary zone electrophoresis (ITP/CZE) in a single capillary prior to mass spectrometric detection is described for clenbuterol and some analogues. Concentration detection limits were found to be in the nanogram per millilitre range. The applicability of ITP/CZE/MS as a trace analysis technique is demonstrated by the determination of some β‐agonists in calf urine.