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Identification of clozapine N + ‐glucuronide in the urine of patients treated with clozapine using electrospray mass spectrometry
Author(s) -
Luo H.,
McKay G.,
Midha K. K.
Publication year - 1994
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200230305
Subject(s) - glucuronide , chromatography , urine , chemistry , electrospray mass spectrometry , mass spectrometry , electrospray , clozapine , medicine , biochemistry , schizophrenia (object oriented programming) , psychiatry
Clozapine N + ‐glucuronide was detected in the urine of five patients chronically treated with clozapine. Identification was made on the basis that the material isolated from urine had the same high‐performance liquid chromatographic retention time and positive electrospray mass spectra as that of an authentic reference standard of clozapine N + ‐glucuronide. These results indicate that electrospray mass spectrometry is a valuable technique in the analysis of low‐molecular‐weight biologically derived N + ‐glucuronide metabolites.