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Mass spectrometry and liquid chromatography/mass spectrometry of some derivatives of 6‐(2‐chlorophenyl)‐1‐methyl‐7,8,9,10‐tetrahydro‐4 H ‐pyrido [4′,3′ ‐ 4,5]thieno [3,2‐ f ] [1,2,4]triazolo [4,3‐ a ] [1,4]diazepines
Author(s) -
Celma C.
Publication year - 1994
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200230104
Subject(s) - thermospray , chemistry , mass spectrometry , electron ionization , mass spectrum , deuterium , chemical ionization , fragmentation (computing) , analytical chemistry (journal) , chromatography , medicinal chemistry , ionization , ion , organic chemistry , tandem mass spectrometry , selected reaction monitoring , physics , quantum mechanics , computer science , operating system
Electron impact and isobutane positive and negative chemical ionization mass spectra of some 6‐(2‐chlorophenyl)‐1‐methyl‐7,8,9,10‐tetrahydro‐4 H ‐pyrido [4′,3′‐4,5]thieno [3,2‐ f ] [1,2,4] triazolo [4,3‐ a ] [1,4] diazepine derivatives have been determined and their fragmentation pattern elucidated with the aid of deuterium labelling and high‐resolution mass measurements. Liquid chromatography/mass spectrometry using both thermospray and particle beam interfaces of such compounds also have been carried out. The most significant ions were derived from the thermal decomposition of the molecules giving the 6‐(2‐chlorphenyl)‐1‐methyl‐7,8,9,10‐tetrahydro‐ 4 H ‐pyrido [4′,3′‐4,5] thieno [3,2‐ f ] [1,2,4] triazolo [4,3‐ a ] [1,4] diazepine framework and an isothiocyanate or an isocyanate residue.