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On‐line high‐performance liquid chromatographic/gas chromatographic/tandem ion trap mass spectrometric determination of levamisole in milk
Author(s) -
Chappell Colin G.,
Creaser Colin S.,
Stygall James W.,
Shepherd Martin J.
Publication year - 1992
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200211211
Subject(s) - chromatography , chemistry , mass spectrometry , ion trap , tandem mass spectrometry , quadrupole ion trap , gas chromatography , mass spectrum , analytical chemistry (journal) , levamisole , extraction (chemistry) , resolution (logic) , tandem , electron ionization , detection limit , ion , ionization , materials science , medicine , organic chemistry , artificial intelligence , computer science , composite material
On‐line high‐performance liquid chromatography/high‐resolution gas chromatography/tandem mass spectrometry, performed on a quadrupole ion trap, has been used as a rapid method for the quantification of the anthelmintic drug levamisole in raw milk extracts following a simple extraction procedure. Detection at the 0.5 p.p.b. level and a linear response in the 10‐0.5 p.p.b. range is demonstrated. Multiple‐scan monitoring techniques have been used to acquire chemical ionization tandem mass spectra and electron impact mass spectra in a single chromatographic run.