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Identification of O ‐methyldopa in the ventricular fluid of patients with Parkinson's disease
Author(s) -
Ikarashi Yasushi,
Maruyama Yuji
Publication year - 1992
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200210803
Subject(s) - neurochemical , metabolite , chemistry , mass spectrometry , chromatography , high performance liquid chromatography , biological fluids , parkinson's disease , disease , medicine , biochemistry
A newly developed liquid chromatographic system with a multiple electrode detector was used for quantification of neurochemical substances in ventricular fluid of patients with Parkinson's disease. During the analysis, an unknown peak was observed at almost the same high‐performance liquid chromatography retention time as 5‐hydroxytryptophan. Through the use of ion suppression techniques, voltammographic analysis and fast atom bombardment mass spectrometry, the compound was identified as O ‐methyldopa, the major metabolite of L‐dopa.