Premium
Simultaneous determination of tenidap and its stable isotope analog in serum by high‐performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry
Author(s) -
Avery M. J.,
Mitchell D. Y.,
Falkner F. C.,
Fouda H. G.
Publication year - 1992
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200210706
Subject(s) - atmospheric pressure chemical ionization , bioequivalence , chromatography , chemistry , analyte , chemical ionization , tandem , tandem mass spectrometry , pharmacokinetics , mass spectrometry , liquid chromatography–mass spectrometry , analytical chemistry (journal) , ionization , pharmacology , organic chemistry , medicine , ion , materials science , composite material
A specific high‐performance liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometric assay for the quantitative determination of tenidap and its D 3 analog in human serum is described. The assay exhibited a linear dynamic range of 0.1‐25 μg ml −1 . Its precision for the two analytes over the range was 17% or better. The assay validity and its utility to investigate changes in tenidap bioequivalence and pharmacokinetics are presented.