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Application of collisionally activated decomposition mass‐analysed ion kinetic energy spectrometry to a survey of sheep milk for benzimidazole residues in relation to withdrawal periods
Author(s) -
Facino R. Maffei,
Carini M.,
Traldi P.
Publication year - 1992
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200210404
Subject(s) - fenbendazole , benzimidazole , chemistry , mass spectrometry , detection limit , anthelmintic , chromatography , electron capture detector , analytical chemistry (journal) , selected ion monitoring , electron ionization , ion , ionization , gas chromatography–mass spectrometry , biology , organic chemistry , ecology
A collisional spectroscopy procedure for simultaneous detection of five widely employed benzimidazole anthelmintics (laevamisole, thiabendazole, mebendazole, fenbendazole, febantel) in sheep milk was developed. The method which involves injection of crude milk extracts and selection and collision of the most abundant ionic species (M +˙ or fragments) obtained under electron impact ionization, is highly suitable for multi‐residue analysis because of its sensitivity (limits of detection in the range of 0.6‐2.8 p.p.b) and its rapidity (more than five samples per hour can be processed). The collisional approach was applied successfully for monitoring of anthelmintic residues in sheep milk.