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Evaluation of inductively coupled mass spectrometry for the determination of platinum in plasma
Author(s) -
Allain P.,
Berre S.,
Mauras Y.,
Le Bouil A.
Publication year - 1992
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200210305
Subject(s) - inductively coupled plasma mass spectrometry , platinum , chemistry , reproducibility , mass spectrometry , detection limit , inductively coupled plasma , chromatography , analytical chemistry (journal) , dilution , isotope dilution , plasma , biochemistry , physics , quantum mechanics , thermodynamics , catalysis
Among the different analytical methods used for the determination of platinum in blood plasma from patients treated by platinum derivatives, inductively coupled plasma mass spectrometry appears to be the most sensitive (detection limit 0.05 μg 1 −1 ) and the best adapted for measuring low concentrations. The preparation of the samples consisted only of a dilution. The recoveries were close to 100% and both within‐run and between‐days reproducibility were very good. The determination of free patinum which was only about 5% of total plasma platinum was chosen to illustrate the inductively coupled mass spectrometric method.