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Molecular characterization of diclofenac and its hydroxylated metabolites by tandem mass spectrometry
Author(s) -
Rubino Federico M.,
Zecca Luigi
Publication year - 1992
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200210209
Subject(s) - fast atom bombardment , chemistry , tandem mass spectrometry , mass spectrometry , diclofenac , electron ionization , tandem , aryl , chromatography , chemical ionization , protein mass spectrometry , ionization , organic chemistry , biochemistry , ion , alkyl , materials science , composite material
A mass spectrometric investigation on the anti‐inflammatory drug o ‐(2,6‐dichlorophenyl)aminophenylacetic acid (Diclofenac) and its hydroxylated metabolites is performed by means of electron impact, chemical ionization and fast atom bombardment. Tandem mass spectrometry of isomeric monohydroxylated compounds allows assessment of the substitution pattern on the two aryl rings.