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Characterization of putative neurotransmitter N ‐acetyl‐aspartyl‐glutamic acid and some related compounds by fast atom bombardment and tandem mass spectrometry
Author(s) -
Rubino Federico Maria,
Zecca Luigi,
Chillemi Francesco
Publication year - 1992
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200210205
Subject(s) - fast atom bombardment , chemistry , mass spectrometry , tandem mass spectrometry , collision induced dissociation , glutamic acid , dissociation (chemistry) , tandem , ion , amino acid , stereochemistry , chromatography , biochemistry , organic chemistry , materials science , composite material
The characterization of the N ‐blocked neuropeptide N ‐acetyl‐aspartyl‐glutamic acid and of some related compounds was carried out by negative‐ion fast atom bombardment mass spectrometry and collision‐induced dissociation of the generated [M ‐ H] − species. Thorough analysis of the fragment ion spectra allowed discrimination between sequence isomeric compounds, and highlighting of differences between dipeptides linked in the normal or iso mode.