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Mass spectrometry of thermorubin antibiotics
Author(s) -
Edwards Duncan M. F.,
Vékey Károly,
Galimberti Marina
Publication year - 1992
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200210109
Subject(s) - thermospray , fast atom bombardment , mass spectrometry , ionization , mass spectrum , chemistry , chemical ionization , analytical chemistry (journal) , ion , polyatomic ion , chromatography , organic chemistry , tandem mass spectrometry , selected reaction monitoring
Different soft introduction and ionization methods, including fast atom bombardment, particle beam chemical ionization, thermospray and direct liquid introduction (DLI) have been compared for the analysis of thermorubin, a thermally labile antibiotic of molecular weight 600. Emphasis is placed on distinguishing thermally induced processes, which may complicate the interpretation of liquid chromatographic mass spectra of synthetic derivatives: the study draws in particular on results of DLI negative ion experiments on thermorubin and related compounds.