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Sequencing of cyclodepsipeptides (destruxins) using positive fast atom bombardment desorption tandem mass spectrometry
Author(s) -
Lange C.,
Mulheim C.,
Vey A.,
Pais M.
Publication year - 1992
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200210108
Subject(s) - fast atom bombardment , tandem , isobaric labeling , mass spectrometry , tandem mass spectrometry , chemistry , deuterium , tandem mass tag , isobaric process , ion , resolution (logic) , atom (system on chip) , analytical chemistry (journal) , chromatography , protein mass spectrometry , materials science , physics , proteomics , computer science , atomic physics , organic chemistry , quantitative proteomics , biochemistry , artificial intelligence , composite material , gene , thermodynamics , embedded system
The development of fast atom bombardment tandem mass spectrometry methodology is applied to the sequencing of the destruxin toxins (cyclodepsipeptides) which are ‘wrong’ cyclopeptides. The strategy is discussed in detail. Possible ways to overome problems related to the resolution of isobaric fragment ions using deuterated compounds and the distinction between sequence and retrosequence are examined.