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Gas chromatographic/mass spectrometric identification of 3‐hydroxydicarboxylic acids in urine
Author(s) -
Verhaeghe B. J.,
Van Bocxlaer J. F.,
De Leenheer A. P.
Publication year - 1992
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200210107
Subject(s) - trimethylsilyl , chromatography , mass spectrometry , methylene , chemistry , urine , gas chromatography , gas chromatography–mass spectrometry , electron ionization , chemical ionization , ionization , organic chemistry , ion , biochemistry
Organic acid profiles were routinely analysed for two patients suffering from a massive 3‐hydroxydicarboxyluria and five patients suffering from ketoaciduria. The identification of the urinary, saturated and unsaturated 3‐hydroxydicarboxylic acids as their trimethylsilyl derivatives was performed with electron impact and positive chemical ionization gas chromatography/mass spectrometry. Additionally, their methylene units have been determined on SE‐52 and OV‐1701 types of stationary phases.