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Investigations of animal blood samples after fragrance drug inhalation by gas chromatography/mass spectrometry with chemical ionization and selected ion monitoring
Author(s) -
Jirovetz L.,
Jäger W.,
Buchbauer G.,
Nikiforov A.,
Raverdinno V.
Publication year - 1991
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200201210
Subject(s) - mass spectrometry , chromatography , gas chromatography–mass spectrometry , gas chromatography , chemical ionization , chemistry , environmental chemistry , inhalation , ionization , ion , medicine , organic chemistry , anesthesia
The fragrance compounds linalool (1) and linalyl acetate (2) could be detected, identified and quantified (1: 7–9 ng ml −1 ; and 2: 1–2 ng ml −1 and 4–5 ng ml −1 as free linalool) in blood samples after inhalation in animal experiments (mice) by gas chromatography/mass spectrometry (GC/MS) with chemical ionization (CI) (ammonia); selected ion monitoring (SIM) mode (1: m / z 81, 137 and 154; 2: 47, 57 and 137) and GC/flame ionization detection (FID). The inhalation of these monoterpenes in concentrations of 5 mg I −1 air leads to a significant reduction of the motility of the test animals down to 30–40% with respect to the control group.