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Fragmentation characteristics of N ‐dialkyloxyphosphinylpeptides under fast atom bombardment
Author(s) -
Ma XiaoBo,
Zhao YuFen
Publication year - 1991
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200200811
Subject(s) - fast atom bombardment , fragmentation (computing) , ion , chemistry , protonation , tripeptide , alkene , mass spectrum , polyatomic ion , molecule , fragment (logic) , stereochemistry , peptide , organic chemistry , biochemistry , computer science , catalysis , programming language , operating system
Abstract The positive ion fast atom bombardment (FAB) mass spectral fragmentations of N ‐diisopropyloxyphosphinyl and N ‐dibutyloxyphosphinyl di‐ or tripeptides were carefully investigated. Results showed that the intense peaks involving base peaks were only the N ‐phosphoryl fragment ions while the C‐terminal series ions and other ions derived from glycerol matrix were greatly suppressed. Successive McLafferty‐type rearrangements to eliminate alkene were observed for protonated molecular ions and all N ‐phosphoryl fragment ions formed. These merits make it possible to use phosphoryl as better N ‐protected groups than others in the FAB mass spectrometric sequence analysis of peptides.