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Dimethylisopropylsilyl ether derivative in gas chromatography/mass spectrometry of 2,3‐dinor‐11‐dehydrothromboxane B 2
Author(s) -
Ishibashi Masataka,
Watanabe Keiko,
Ishizaki Fumiko,
Ohyama Yoshiharu,
Nishikawa Masazumi,
Mizugaki Michinao,
Harima Noriaki
Publication year - 1991
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200200702
Subject(s) - chemistry , mass spectrum , ether , dimer , derivative (finance) , mass spectrometry , gas chromatography , fast atom bombardment , ring (chemistry) , hydrocarbon , fragmentation (computing) , medicinal chemistry , chromatography , organic chemistry , financial economics , economics , computer science , operating system
The mass spectrum of the 2,3‐dinor‐11‐dehydrothromboxane B 2 (DNDTXB 2 ) 1‐methyl ester‐11‐ n ‐propylamide‐9,12,15‐tris‐dimethylisopropylsilyl ether derivative was characterized by the base peak ion [M C 3 H 7 ] + ( m / z 670), and it exhibited a series of ions typical of the expected derivative. Many of the fragmentation products could be explained in terms of their simple bond fission mechanisms. Ions containing silicon atom in the low‐mass region were produced via a six‐membered ring transition or by formation of the cyclic dimethylsilylene ring system, which were common to the TXB metabolites having a δ‐lactone ring system. These results revealed that this mass spectrum was similar to that of the corresponding 11‐dehydro‐TXB 2 derivative except for the obvious shift produced by the lack of C2/C3 hydrocarbon units. The presence of DNDTXB 2 in the urine of a healthy adult was confirmed by gas chromatography/selected ion monitoring.